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| Morgan Freeman | Brig. Gen. Billy Ford | |
| Dustin Hoffman | Col. Sam Daniels | |
| Rene Russo | Robby Keough | |
| Kevin Spacey | Maj. Casey Schuler | |
| Donald Sutherland | Maj. Gen. Donald McClintock | |
| Malick Bowens | Dr. Raswani | |
| Patrick Dempsey | Jimbo Scott | |
| Cuba Gooding Jr. | Maj. Salt | |
| Susan Lee Hoffman | Dr. Lisa Aronson | |
| Zakes Mokae | Dr. Benjamin Iwabi |
| Director |
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| Producer | Arnold Kopelson
Wolfgang Petersen |
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| Writer | Robert Roy Pool
Laurence Dworet |
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| Cinematography | Michael Ballhaus
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| Musician | James Newton Howard
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A deadly airborne virus finds its way into the USA and starts killing off people at an epidemic rate. Col Sam Daniels' job is to stop the virus spreading from a small town, which must be quarantined, and to prevent an over reaction by the White House. |
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